As part of a joint basic technology programme with members of the Nanoscience centre and Physics of Medicine we are developing a novel device with which it is possible to make electrical recordings from nerve fibres.
In damaged nerves, the fibres can grow through the interface, or nerves can be dissected and the teased strands inserted.
Using this device we have developed a strategy for restoring control to the bladder following spinal cord injury.
A device for bladder control in dogs with spinal cord injury is now in clinical use.
Chew DJ, Zhu l, elivopoulos E, Minev I, ., Musick KM, Mosse CA, Craggs M, Donaldson N, Lacour SP, McMahon SB, Fawcett JW (2013) A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat. Sci Transl Med 5:210ra155.
Granger N, Chew D, Fairhurst P, Fawcett JW, Lacour SP, Craggs M, Mosse CA, Donaldson N, Jeffery ND (2013) Use of an implanted sacral nerve stimulator to restore urine voiding in chronically paraplegic dogs. J Vet Intern Med 27:99-105.
Minev IR, Chew DJ, Delivopoulos E, Fawcett JW, Lacour SP (2012) High sensitivity recording of afferent nerve activity using ultra-compliant microchannel electrodes: an acute in vivo validation. J Neural Eng 9:026005.
FitzGerald JJ, Lacour SP, Fawcett JW. Recording with microchannel electrodes in a noisy environment. Conf Proc IEEE Eng Med Biol Soc 2008; 1: 34-37.