Principal Investigator, Cambridge Centre for Brain Repair
Department of Clinical Neurosciences, University of Cambridge
Consultant in Clinical Neurology, Department of Neurology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Trust.
We are interested in the role of Rho family GTPases and their regulators in the plasticity of CNS synapses, as related to brain disease and recovery from brain injury. We use in vitro cell culture models to understand what role this molecule plays in the homeostatic regulation of synapse number in developing and adult brain.
Roma Rambaran (Research Assistant)
Adrian Tan (M. Phil student)
Alzheimer’s Research UK
A hippocampal neurone filled with
greenfluorescent protein (GFP) and labelled for
pre-synaptic (blue) and post-synaptic (red) structures.
Marland, J.R.K., Pan, D., and Buttery, P.C. (2011). Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons. Journal of Biological Chemistry 286, 199–207.
Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P (2006), “The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology” Proc Natl Acad Sci USA 103(6):1924-9
Buttery P, Mason C (2003), “Maintaining stability in the face of change” Nat Neurosci 6(11):1117-9