John van Geest Centre for Brain Repair

School of Clinical Medicine



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Peter Hutchinson

Professor of Neurosurgery

Senior Academy Fellow and Honorary Consultant Neurosurgeon

Peter Hutchinson BSc (hons), MBBS, PhD, FRCS (Surg Neurol) is Professor and Head of Department  of Neurosurgery and Academy of Medical Sciences / Health Foundation Senior Surgical Scientist Fellowship within the Department of Clinical Neurosciences, University of Cambridge and Honorary Consultant Neurosurgeon post at Addenbrooke’s Hospital. He has a general neurosurgical practice with a sub-specialist interest in the management of neuro-trauma. He has a research interest in traumatic brain injury (PI of the MRC / NIHR funded www.RESCUEicp decompressive study), multimodality monitoring in neuro-critical care and functional imaging. He was the previous chair of the EANS Research Committee and is now a Vice-President of the EANS, has co-authored over 160 publications and is joint editor of the book “Head Injury – A Multidisciplinary Approach”. He is currently chair of the Society of British Neurosurgeons Neurotrauma Group and a member of the SBNS council, Director of Clinical Studies and Fellow at Robinson College Cambridge, and Deputy Chief Medical Officer for the British Grand Prix.

Research focus

My research areas include acute brain injury (head injury, subarachnoid haemorrhage), decompressive craniectomy in head injury and stroke, multimodality monitoring (intracranial pressure, brain tissue oxygen, intracerebral microdialysis), brain imaging (PET and MRI) and cerebral tumours (microdialysis, gene therapy).

Key publications
Helmy A, Antoniades CA, Guilfoyle MR, Carpenter KL, Hutchinson PJ. PLoS One. 2012;7(6):e39677. Epub 2012 Jun 22. Principal component analysis of the cytokine and chemokine response to human traumatic brain injury. PMID: 22745809

Keong NC, Bulters DO, Richards HK, Farrington M, Sparrow OC, Pickard JD, Hutchinson PJ, Kirkpatrick PJ. The SILVER (Silver Impregnated Line Versus EVD Randomized trial): a double-blind, prospective, randomized, controlled trial of an intervention to reduce the rate of external ventricular drain infection. Neurosurgery. 2012 Aug;71(2):394-403; discussion 403-4. PMID: 22811084

Helmy A, De Simoni MG, Guilfoyle MR, Carpenter KL, Hutchinson PJ. Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury. Prog Neurobiol. 2011 Nov;95(3):352-72. Epub 2011 Sep 16. PubMed PMID: 21939729.

Timofeev I, Czosnyka M, Carpenter KL, Nortje J, Kirkpatrick PJ, Al-Rawi PG, Menon DK, Pickard JD, Gupta AK, Hutchinson PJ. Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location. J Neurotrauma. 2011 Jun;28(6):849-60. PubMed PMID: 21488707; PubMed Central PMCID: PMC3113421.

Timofeev I, Carpenter KL, Nortje J, Al-Rawi PG, O’Connell MT, Czosnyka M, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ. Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients. Brain. 2011 Feb;134(Pt 2):484-94. Epub 2011 Jan 18. PubMed PMID: 21247930.

Helmy A, Carpenter KL, Menon DK, Pickard JD, Hutchinson PJ. The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production. J Cereb Blood Flow Metab. 2011 Feb;31(2):658-70. Epub 2010 Aug 18. PubMed PMID: 20717122.

Al-Rawi PG, Tseng MY, Richards HK, Nortje J, Timofeev I,   Matta BF, Hutchinson PJ, Kirkpatrick PJ. Hypertonic saline in patients with poor-grade subarachnoid hemorrhage improves cerebral blood flow, brain tissue oxygen, and pH. Stroke. 2010 Jan;41(1):122-8. Epub 2009 Nov 12. PubMed PMID: 19910550.

Gallagher CN, Carpenter KL, Grice P, Howe DJ, Mason A, Timofeev I, Menon DK, Kirkpatrick PJ, Pickard JD, Sutherland GR, Hutchinson PJ. The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study. Brain. 2009 Oct;132(Pt 10):2839-49. Epub 2009 Aug 20. PubMed PMID: 19700417.

Santarius T, Kirkpatrick PJ, Ganesan D, Chia HL, Jalloh I, Smielewski P, Richards HK, Marcus H, Parker RA, Price SJ, Kirollos RW, Pickard JD, Hutchinson PJ. Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial. Lancet. 2009 Sep 26;374(9695):1067-73. PubMed PMID: 19782872.

Mendelow AD, Timothy J, Steers AJW, Lecky F, Yates D, Bouamra O,  Woodford M, Hutchinson PJ. Management of Patients with Head Injury: Lancet 2008; 23: 685-7

Mannion RJ, Cross J, Bradley P, Coles JP, Chatfield D, Carpenter A, Pickard JD, Menon DK, Hutchinson PJ (2007), “A mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome” J Neurotrauma 24:128-35 Details

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