Emeritus Professor of Neurosurgery
NHS Divisional Director for Neurosciences.
Pathophysiological consequences of a floating brain; advancing the care of patients with acute brain injury (trauma, haemorrhage and hydrocephalus) from initial ictus, neurointensive care, recovery from coma and rehabilitation to final outcome through the study of pathophysiology (multimodality bedside monitoring, PET and MR imaging – Wolfson Brain Imaging Centre), randomised controlled trials, UK Shunt Evaluation Laboratory and Shunt Registry and refining the rehabilitation pathway for our 2.6M population in the Eastern Region. Discoveries have included definition of how early insults to the brain in both childhood and later life may lead to late changes and cognitive outcome, new ways of detecting when the blood supply to critical areas of the brain become at risk, which treatments may be helpful (acute statin, decompressive craniectomy) and which counterproductive, detection of covert awareness in the ‘vegetative ‘ state, which parts of the brain are affected in normal pressure hydrocephalus and novel treatments for pseudotumor cerebri and cerebral venous disorders.
Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD (2006), “Detecting awareness in the vegetative state” Science 313:1402.
Coleman MR, Davis MH, Rodd JM, Robson T, Ali A, Owen AM, Pickard JD. Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness. Brain. 2009;132:2541-52.
Monti MM, Vanhaudenhuyse A, Coleman MR, Boly M, Pickard JD, Tshibanda L, Owen AM, Laureys S. Willful modulation of brain activity in disorders of consciousness. N Engl J Med. 2010;362:579-89
Lu CW, Czosnyka M, Shieh JS, Smielewska A, Pickard JD, Smielewski P. Complexity of intracranial pressure correlates with outcome after traumatic brain injury. Brain. 2012;135:2399-408.