John van Geest Centre for Brain Repair

School of Clinical Medicine



In this section


Recent Papers

Franssen EH, Zhao RR, Koseki H, Kanamarlapudi V, Hoogenraad CC, Eva R, Fawcett JW (2015) Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS. J.Neurosci.

Tan CL, Kwok JC, Heller JP, Zhao R, Eva R, Fawcett JW (2015) Full length talin stimulates integrin activation and axon regeneration. Mol Cell Neurosci.

Yang S, Cacquevel M, Saksida LM, Bussey TJ, Schneider BL, Aebischer P, Melani R, Pizzorusso T, Fawcett JW, Spillantini MG (2015) Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology. Exp Neurol 265:48-58.

Alves JN, Muir EM, Andrews MR, Ward A, Michelmore N, Dasgupta D, Verhaagen J, Moloney EB, Keynes RJ, Fawcett JW, Rogers JH (2014) AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations. J Neurosci Methods 227:107-120.

Eva R, Fawcett J (2014) Integrin signalling and traffic during axon growth and regeneration. Curr Opin Neurobiol 27C:179-185.

Heintz TG, Heller JP, Zhao R, Caceres A, Eva R, Fawcett JW (2014) Kinesin KIF4A transports integrin beta1 in developing axons of cortical neurons. Mol Cell Neurosci 63:60-71.

Kappagantula S, Andrews MR, Cheah M, Abad-Rodriguez J, Dotti CG, Fawcett JW (2014) Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons. J Neurosci 34:2477-2492.

Kwok JC, Heller JP, Zhao RR, Fawcett JW (2014) Targeting inhibitory chondroitin sulphate proteoglycans to promote plasticity after injury. Methods Mol Biol 1162:127-138.

Kwok JC, Yang S, Fawcett JW (2014) Neural ECM in regeneration and rehabilitation. Prog Brain Res 214:179-192.

Moshayedi P, Ng G, Kwok JC, Yeo GS, Bryant CE, Fawcett JW, Franze K, Guck J (2014) The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system. Biomaterials 35:3919-3925.

Chew DJ, Zhu l, elivopoulos E, Minev I, ., Musick KM, Mosse CA, Craggs M, Donaldson N, Lacour SP, McMahon SB, Fawcett JW (2013) A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat. Sci Transl Med 5:210ra155.

Dassie E, Andrews MR, Bensadoun JC, Cacquevel M, Schneider BL, Aebischer P, Wouters FS, Richardson JC, Hussain I, Howlett DR, Spillantini MG, Fawcett JW (2013) Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model. Neurobiol Aging 34:1355-1368.

Dick G, Tan CL, Alves JN, Ehlert EM, Miller GM, Hsieh-Wilson LC, Sugahara K, Oosterhof A, van Kuppevelt TH, Verhaagen J, Fawcett JW, Kwok JC (2013) Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains. J Biol Chem 288:27384-27395.

Granger N, Chew D, Fairhurst P, Fawcett JW, Lacour SP, Craggs M, Mosse CA, Donaldson N, Jeffery ND (2013) Use of an implanted sacral nerve stimulator to restore urine voiding in chronically paraplegic dogs. J Vet Intern Med 27:99-105.

Gumy LF, Chew DJ, Tortosa E, Katrukha EA, Kapitein LC, Tolkovsky AM, Hoogenraad CC, Fawcett JW (2013) The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration. J Neurosci 33:11329-11345.

Minev IR, Moshayedi P, Fawcett JW, Lacour SP (2013) Interaction of glia with a compliant, microstructured silicone surface. Acta Biomater.

Romberg C, Yang S, Melani R, Andrews MR, Horner AE, Spillantini MG, Bussey TJ, Fawcett JW, Pizzorusso T, Saksida LM (2013) Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex. J Neurosci 33:7057-7065.

Soleman S, Filippov MA, Dityatev A, Fawcett JW (2013) Targeting the neural extracellular matrix in neurological disorders. Neuroscience 253C:194-213.

Vo T, Carulli D, Ehlert EM, Kwok JC, Dick G, Mecollari V, Moloney EB, Neufeld G, De WF, Fawcett JW, Verhaagen J (2013) The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain. Mol Cell Neurosci 56C:186-200.

Vorobyov V, Kwok JC, Fawcett JW, Sengpiel F (2013) Effects of digesting chondroitin sulfate proteoglycans on plasticity in cat primary visual cortex. J Neurosci 33:234-243.

Zhao RR, Andrews MR, Wang D, Warren P, Gullo M, Schnell L, Schwab ME, Fawcett JW (2013) Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury. Eur J Neurosci 38:2946-2961.


Supplementary material (movies)

Richard Eva, Sarah Crisp, Jamie R. K. Marland, Jim C. Norman, Venkateswarlu
Kanamarlapudi, Charles ffrench-Constant, James W. Fawcett. (2012) ARF6 Directs Axon Transport and Traffic of Integrins, and Regulates Axon Growth in Adult DRG Neurons

Eva Movie 1_PC12 ARF6 Beta1

Eva Movie 2_PC12 ARF6 Alpha9

Eva Movie 3_DRG Alpha9

Eva Movie 4_DRG Alpha9 plus ACAP1

Eva Movie 5_DRG Alpha9 plus ACAP1 R448Q

Eva Movie 6_DRG Alpha9 plus ARNO

Eva Movie 7_DRG Alpha9 plus EFA6


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