John van Geest Centre for Brain Repair

School of Clinical Medicine

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David Menon

davidDavid Menon is Professor and Head of the Department of Anaesthesia, Principal Investigator in the Wolfson Brain Imaging Centre, and Co-Chair of the Acute Brain Injury Programme at the University of Cambridge. He holds an NIHR Senior Investigator award.

He trained in Medicine, Anaesthesia and Intensive Care at the Jawaharlal Institute in India, Leeds General Infirmary, The Royal Free Hospital and Addenbrooke’s Hospital, and was an MRC Research Fellow at the Hammersmith Hospital prior to coming to Cambridge.

In 2006 he was appointed to the British Oxygen Professorship at the Royal College of Anaesthetists. He is Co-Chair of the Executive Board of the European Brain Injury Consortium, is a Founding Fellow of the Academy of Medical Sciences, and a Prorafessorial Fellow in the Medical Sciences at Queens’ College, Cambridge.

He was the first Director of the Neurosciences Critical Care Unit (NCCU) at Addenbrooke’s Hospital, Cambridge, where he established the first recognised training programme for specialist neurocritical care in the UK. Protocols developed in the Addenbrooke’s NCCU have been shown to improve clinical outcome in severe head injury and rationalise the management of acute intracranial haemorrhage.

Professor Menon’s research interests include neurocritical care, secondary brain injury, neuroinflammation, and metabolic imaging of acute brain injury. He has also published on the physiology of coma and the vegetative state, and on mechanisms of anaesthetic action in the brain. In recent years he has represented the UK intensive care community in discussions regarding the impact of evolving legislative changes on research in critical care and emergency medicine. Click here for a list of his publications.
dkm13@wbic.cam.ac.uk
Tel: +44 (0)1223 217889

Publications

2008

Bernard F, Al-Tamimi YZ, Chatfield D, Lynch AG, Matta BF, Menon DK (2008), “Serum albumin level as a predictor of outcome in traumatic brain injury: potential for treatment.” J Trauma 64(4):872-5 Details

Maiya B, Newcombe V, Nortje J, Bradley P, Bernard F, Chatfield D, Outtrim J, Hutchinson P, Matta B, Antoun N, Menon D (2008), “Magnetic resonance imaging changes in the pituitary gland following acute traumatic brain injury.” Intensive Care Med 34(3):468-75 Details

Menon D, Harrison D (2008), “Prognostic modelling in traumatic brain injury.” BMJ 336(7641):397-8 Details

Nortje J, Coles JP, Menon DK (2008), “Normobaric hyperoxia-A further treatment option following traumatic brain injury?” Crit Care Med 36(5):1698

Polderman KH, Menon DK, Girbes AR (2008), “Treating intracranial hypertension in traumatic brain injury: keep it cool!” Intensive Care Med Details

Standley TD, Smith HL, Brennan LJ, Wilkins IA, Bradley PG, Barrera Groba C, Davey AJ, Menon DK, Wheeler DW (2008), “Room air dilution of heliox given by facemask.” Intensive Care Med Details

Wheeler DW, Carter JJ, Murray LJ, Degnan BA, Dunling CP, Salvador R, Menon DK, Gupta AK (2008), “The effect of drug concentration expression on epinephrine dosing errors: a randomized trial.” Ann Intern Med 148(1):11-4 Details

Wheeler DW, Degnan BA, Sehmi JS, Burnstein RM, Menon DK, Gupta AK (2008), “Variability in the concentrations of intravenous drug infusions prepared in a critical care unit.” Intensive Care Med Details

2007

Absalom AR, Lee M, Menon DK, Sharar SR, De Smet T, Halliday J, Ogden M, Corlett P, Honey GD, Fletcher PC (2007), “Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers.” Br J Anaesth 98(5):615-23 Details

Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P, Menon DK, Caldwell MA (2007), “Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo.” Exp Neurol 204(2):512-24 Details

Beech JS, Wheeler DW, Reckless J, Grant AJ, Price J, Mastroeni P, Grainger DJ, Menon DK (2007), “The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro.” J Neuroimmunol 184(1-2):198-208 Details

Coleman MR, Rodd JM, Davis MH, Johnsrude IS, Menon DK, Pickard JD, Owen AM (2007), “Do vegetative patients retain aspects of language comprehension? Evidence from fMRI.” Brain 130(Pt 10):2494-507 Details

Coles JP, Fryer TD, Coleman MR, Smielewski P, Gupta AK, Minhas PS, Aigbirhio F, Chatfield DA, Williams GB, Boniface S, Carpenter TA, Clark JC, Pickard JD, Menon DK (2007), “Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.” Crit Care Med 35(2):568-78 Details

Hutchinson PJ, O’Connell MT, Rothwell NJ, Hopkins SJ, Nortje J, Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD (2007), “Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra.” J Neurotrauma 24(10):1545-57 Details

Jansen TC, Kompanje EJ, Druml C, Menon DK, Wiedermann CJ, Bakker J (2007), “Deferred consent in emergency intensive care research: what if the patient dies early? Use the data or not?” Intensive Care Med 33(5):894-900 Details

Lavinio A, Timofeev I, Nortje J, Outtrim J, Smielewski P, Gupta A, Hutchinson PJ, Matta BF, Pickard JD, Menon D, Czosnyka M (2007), “Cerebrovascular reactivity during hypothermia and rewarming.” Br J Anaesth 99(2):237-44 Details

Mannion RJ, Cross J, Bradley P, Coles JP, Chatfield D, Carpenter A, Pickard JD, Menon DK, Hutchinson PJ (2007), “Mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome.” J Neurotrauma 24(1):128-35 Details

Newcombe VF, Williams GB, Nortje J, Bradley PG, Harding SG, Smielewski P, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2007), “Analysis of acute traumatic axonal injury using diffusion tensor imaging.” Br J Neurosurg 21(4):340-8 Details

Reid CL, Menon DK (2007), “Researching incapacity: Time to get our acts together.” BMJ 335(7617):415 Details

Sharshar T, Carlier R, Bernard F, Guidoux C, Brouland JP, Nardi O, de la Grandmaison GL, Aboab J, Gray F, Menon D, Annane D (2007), “Brain lesions in septic shock: a magnetic resonance imaging study.” Intensive Care Med 33(5):798-806 Details

Takasawa M, Beech JS, Fryer TD, Hong YT, Hughes JL, Igase K, Jones PS, Smith R, Aigbirhio FI, Menon DK, Clark JC, Baron JC (2007), “Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study.” J Cereb Blood Flow Metab 27(4):679-89

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